RNA Details
Disease Name
Familial Primary Pulmonary Hypertension
Tissue
lung
RNA Symbol
BMPR2
RNA ID
RNA Type
mRNA
Alteration Pattern
dysregulation
Species
homo sapiens
Detection Methods
etc.
Target
NA
Pathway
NA
PubMed ID
Title
Altered MicroRNA processing in heritable pulmonary arterial hypertension: an important role for Smad-8
Year
2011
Function
"Heritable pulmonary arterial hypertension (HPAH) associated BMPR2 and SMAD9 mutation completely abrogated noncanonical Smad-mediated microRNA (miR) processing, leading to miR-21 downregulation, contributing to vascular cell proliferation."